Risk factors for mild cognitive impairment among older adults in a hospital in southern Nigeria.

BACKGROUND: About 63% of people living with mild cognitive impairment (MCI) and dementia live in low- and middle-income countries (LMICs). Emerging evidence suggests that early risk factors for the development of MCI and dementia can be modified by public health and preventive intervention approaches. AIM: This study aimed to assess the prevalence of MCI in older adult patients and its relationship with some risk factors. SETTING: The study was conducted among older adults at the Geriatric Clinic of the Family Medicine Department of a hospital in southern Nigeria. METHODS: A cross-sectional study was carried out involving 160 subjects aged 65 years and above over a period of 3 months. Socio-demographic and clinical data were obtained using an interviewer-administered questionnaire. Subjects were accessed for impaired cognition using the 10-word delay recall test scale. Data were analysed using SPSS version 23. RESULTS: There were 64 males and 96 females; male to female ratio was 1:1.5. Majority of the study population were in age range of 65-74 years. The overall prevalence of MCI was 59.4%. Respondents with tertiary education were 82% less likely to have MCI on logistic regression analysis (OR = 0.18, 95% CI = 0.465-0.719). CONCLUSION: Mild cognitive impairment was prevalent among older adults in this study and was found to be significantly associated with low level of education.Contribution: It is therefore recommended that screening for MCI and known risk factors should be prioritized at geriatric clinics.

Sensitivity and specificity of malaria rapid diagnostic test (mRDT CareStatTM) compared with microscopy amongst under five children attending a primary care clinic in southern Nigeria.

BACKGROUND: Malaria diagnosis using microscopy is currently the gold standard. However, malaria rapid diagnostic tests (mRDTs) were developed to simplify the diagnosis in regions without access to functional microscopy. AIM: The objective of this study was to compare the diagnostic accuracy of mRDT CareStatTM with microscopy. SETTING: This study was conducted in the paediatric primary care clinic of the Federal Medical Centre, Asaba, Nigeria. METHODS: A cross-sectional study for diagnostic accuracy was conducted from May 2016 to October 2016. Ninety-eight participants were involved to obtain a precision of 5%, sensitivity of mRDT CareStatTM of 95% from published work and 95% level of confidence after adjusting for 20% non-response rate or missing data. Consecutive participants were tested using both microscopy and mRDT. The results were analysed using EPI Info Version 7. RESULTS: A total of 98 children aged 3-59 months were enrolled. Malaria prevalence was found to be 53% (95% confidence interval [CI] = 46% - 60%), whilst sensitivity and specificity were 29% (95% CI = 20% - 38%) and 89% (95% CI = 83% - 95%), respectively. The positive and negative predictive values were 75% (95% CI = 66.4% - 83.6%) and 53% (95% CI = 46% - 60%), respectively. CONCLUSION: Agreement between malaria parasitaemia using microscopy and mRDT positivity increased with increase in the parasite density. The mRDT might be negative when malaria parasite density using microscopy is low.

Sensitivity and specificity of malaria rapid diagnostic test (mRDT CareStatTM) compared with microscopy amongst under five children attending a primary care clinic in southern Nigeria

Background: Malaria diagnosis using microscopy is currently the gold standard. However, malaria rapid diagnostic tests (mRDTs) were developed to simplify the diagnosis in regions without access to functional microscopy. Aim: The objective of this study was to compare the diagnostic accuracy of mRDT CareStatTM with microscopy. Setting: This study was conducted in the paediatric primary care clinic of the Federal Medical Centre, Asaba, Nigeria. Methods: A cross-sectional study for diagnostic accuracy was conducted from May 2016 to October 2016. Ninety-eight participants were involved to obtain a precision of 5%, sensitivity of mRDT CareStatTM of 95% from published work and 95% level of confidence after adjusting for 20% non-response rate or missing data. Consecutive participants were tested using both microscopy and mRDT. The results were analysed using EPI Info Version 7. Results: A total of 98 children aged 3­59 months were enrolled. Malaria prevalence was found to be 53% (95% confidence interval [CI] = 46% ­ 60%), whilst sensitivity and specificity were 29% (95% CI = 20% ­ 38%) and 89% (95% CI = 83% ­ 95%), respectively. The positive and negative predictive values were 75% (95% CI = 66.4% ­ 83.6%) and 53% (95% CI = 46% ­ 60%), respectively. Conclusion: Agreement between malaria parasitaemia using microscopy and mRDT positivity increased with increase in the parasite density. The mRDT might be negative when malaria parasite density using microscopy is low